RAD52 est un gène codé par le symbole RAD52. Il est également connu sous le nom de DNA repair protein RAD52 homolog. RAD52 a une masse de 46.17kDa et une longueur d'acide aminé de 418.
Nous proposons 9 des anticorps contre RAD52, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat et Hamster.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Résumé Entrez
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Similitudes de séquence
Belongs to the RAD52 family.
Modification post-traductionnelle
Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.
Localisation cellulaire
Nucleus.
