RAC2 est un gène codé par le symbole RAC2. Il est également connu sous le nom de: Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-RAC2. RAC2 a une masse de 21.43kDa, une longueur d'acide aminé de 192, et est impliqué dans Neutrophil immunodeficiency syndrome.
Nous proposons 7 des anticorps contre RAC2, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Résumé Entrez
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6.
Spécificité tissulaire
Hematopoietic specific.
Implication dans la maladie
Neutrophil immunodeficiency syndrome: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing.
Similitudes de séquence
Belongs to the small GTPase superfamily. Rho family.
Modification post-traductionnelle
(Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
Localisation cellulaire
Cytoplasm.
Membrane-associated when activated.
