Rabphilin 3A est un gène codé par le symbole RPH3A. Il est également connu sous le nom de: Rabphilin-3A; Exophilin-1; RPH3A; KIAA0985. Rabphilin 3A a une masse de 76.87kDa et une longueur d'acide aminé de 694.
Nous proposons 6 des anticorps contre Rabphilin 3A, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity).
Résumé Entrez
The protein encoded by this gene is thought to be an effector for RAB3A, which is a small G protein that acts in the late stages of neurotransmitter exocytosis. The encoded protein may be involved in neurotransmitter release and synaptic vesicle traffic.
Modification post-traductionnelle
Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation.
Localisation cellulaire
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell projection > Dendritic spine. Cell junction > Synapse > Postsynaptic cell membrane. Membrane.
