RAB6A est un gène codé par le symbole RAB6A. Il est également connu sous le nom de: Ras-related protein Rab-6A; Rab-6; RAB6. RAB6A a une masse de 23.59kDa et une longueur d'acide aminé de 208.
Nous proposons 7 des anticorps contre RAB6A, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).
Résumé Entrez
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Spécificité tissulaire
Ubiquitous.
Similitudes de séquence
Belongs to the small GTPase superfamily. Rab family.
Modification post-traductionnelle
Prenylated.
Localisation cellulaire
Golgi apparatus membrane.
BICD2 facilitates its targeting to Golgi apparatus membrane.
