Proteasome Inhibitor subunit 1 PI3 1 est un gène codé par le symbole PSMF1. Communément appelé aussi: Proteasome inhibitor PI31 subunit; hPI31; PSMF1. Proteasome Inhibitor subunit 1 PI3 1 a une masse de 29.82kDa et une longueur d'acide aminé de 271.
Nous proposons 6 des anticorps contre Proteasome Inhibitor subunit 1 PI3 1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Résumé Entrez
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.
Similitudes de séquence
Belongs to the proteasome inhibitor PI31 family.
Localisation cellulaire
Cytoplasm. Endoplasmic reticulum.
