Anticorps PMS2

25 produits

PMS2 est un gène codé par le symbole PMS2. Communément appelé aussi: Mismatch repair endonuclease DNA mismatch repair protein PMS1 protein homolog 2; PMSL2. PMS2 a une masse de 95.8kDa, une longueur d'acide aminé de 862, et est impliqué dans les maladies: Hereditary non-polyposis colorectal cancer 4; Mismatch repair cancer syndrome.

Nous proposons 25 des anticorps contre PMS2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.

Informations sur les Gènes et les Protéines

Résumé UniProt
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.
Résumé Entrez
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
Implication dans la maladie
Hereditary non-polyposis colorectal cancer 4: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.

Mismatch repair cancer syndrome: An autosomal recessive, rare, childhood cancer predisposition syndrome encompassing a broad tumor spectrum. This includes hematological malignancies, central nervous system tumors, Lynch syndrome-associated malignancies such as colorectal tumors as well as multiple intestinal polyps, embryonic tumors and rhabdomyosarcoma. Multiple cafe-au-lait macules, a feature reminiscent of neurofibromatosis type 1, are often found as first manifestation of the underlying cancer. Areas of skin hypopigmentation have also been reported in MMRCS patients.
Similitudes de séquence
Belongs to the DNA mismatch repair MutL/HexB family.
Localisation cellulaire
Nucleus.
Liens de base de données
Western Blot - Anti-PMS2 Antibody [ARC2479] (A309444) - Antibodies.com
(7)
Voir le roduitKO Validé
Western Blot - Anti-PMS2 Antibody (A88039) - Antibodies.com
(4)
Voir le roduitKO Validé
Immunohistochemistry - Anti-PMS2 Antibody [PMS2/4373R] - BSA and Azide free (A252820) - Antibodies.com
(3)
Voir le roduitAnticorps MonospécifiqueAnticorps Recombinant
Immunohistochemistry - Anti-PMS2 Antibody [PMS2/4373R] (A249640) - Antibodies.com
(3)
Voir le roduitAnticorps MonospécifiqueAnticorps Recombinant
Western Blot - Anti-PMS2 Antibody [ARC1039] (A307272) - Antibodies.com
(4)
Western Blot - Anti-PMS2 Antibody (C13104) - Antibodies.com
(3)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-PMS2 Antibody (R12-3341) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-PMS2 Antibody (A15443) - Antibodies.com
Antibodies.com Image Placeholder - Discover more for less
Antibodies.com Image Placeholder - Discover more for less
Immunohistochemistry - Anti-PMS2 Antibody [IHC422] (A324552) - Antibodies.com
Western Blot - Anti-PMS2 Antibody (A305289) - Antibodies.com
Voir le roduitKO Validé
Antibodies.com Image Placeholder - Discover more for less
Voir le roduitAnticorps Recombinant
Antibodies.com Image Placeholder - Discover more for less
Voir le roduitAnticorps Recombinant
Antibodies.com Image Placeholder - Discover more for less
Voir le roduitAnticorps Recombinant
Antibodies.com Image Placeholder - Discover more for less
Voir le roduitAnticorps Recombinant
Anti-PMS2 (D483) Antibody from Bioworld Technology (BS2688) - Antibodies.com
(5)
Anti-PMS2 Antibody from FabGennix (PMS2-212AP) - Antibodies.com
Antibodies.com Image Placeholder - Discover more for less
Antibodies.com Image Placeholder - Discover more for less
Antibodies.com Image Placeholder - Discover more for less
Antibodies.com Image Placeholder - Discover more for less
Antibodies.com Image Placeholder - Discover more for less
Immunohistochemistry - PMS2 Antibody from Signalway Antibody (37216) - Antibodies.com
(2)
Antibodies.com Image Placeholder - Discover more for less

Affichage de 1-25 sur 25 produits

Filtres Menu Principal Nous Contacter 0Caisse
Haut