Plasma Kallikrein 1B est un gène codé par le symbole KLKB1. Communément appelé aussi: Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein; PKK; KLKB1; KLK3. Plasma Kallikrein 1B a une masse de 71.37kDa, une longueur d'acide aminé de 638, et est impliqué dans Prekallikrein deficiency.
Nous proposons 6 des anticorps contre Plasma Kallikrein 1B, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Résumé Entrez
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
Implication dans la maladie
Prekallikrein deficiency: This disorder is a blood coagulation defect.
Similitudes de séquence
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Localisation cellulaire
Secreted.
