PLA2G1B est un gène codé par le symbole PLA2G1B. Communément appelé aussi: Phospholipase A2; Group IB phospholipase A2; Phosphatidylcholine 2-acylhydrolase 1B; PLA2; PLA2A; PPLA2. PLA2G1B a une masse de 16.36kDa et une longueur d'acide aminé de 148.
Nous proposons 7 des anticorps contre PLA2G1B, élevé dans Lapin, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et Dot-Blot avec des échantillons dérivés de Humain, Souris, Rat et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Résumé Entrez
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.
Similitudes de séquence
Belongs to the phospholipase A2 family.
Modification post-traductionnelle
Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
Localisation cellulaire
Secreted.
secreted from pancreatic acinar cells in its inactive form.
