PIAS3 est un gène codé par le symbole PIAS3. Il est également connu sous le nom de E3 SUMO-protein ligase E3 SUMO-protein transferase Protein inhibitor of activated STAT protein 3. PIAS3 a une masse de 68.02kDa et une longueur d'acide aminé de 628.
Nous proposons 8 des anticorps contre PIAS3, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
Résumé Entrez
This gene encodes a member of the PIAS
Spécificité tissulaire
Widely expressed.
Similitudes de séquence
Belongs to the PIAS family.
Modification post-traductionnelle
Sumoylated.
Localisation cellulaire
Cytoplasm. Nucleus. Nucleus speckle.
Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules.
