PIAS1 est un gène codé par le symbole PIAS1. Communément appelé aussi: E3 SUMO-protein ligase DEAD/H box-binding protein 1; E3 SUMO-protein transferase Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein; DDXBP1. PIAS1 a une masse de 71.84kDa et une longueur d'acide aminé de 651.
Nous proposons 7 des anticorps contre PIAS1, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).
Résumé Entrez
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants.
Spécificité tissulaire
Expressed in numerous tissues with highest level in testis.
Similitudes de séquence
Belongs to the PIAS family.
Modification post-traductionnelle
Sumoylated.
Localisation cellulaire
Nucleus speckle. Nucleus > PML body.
Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
