Phospholipase A2 est un gène codé par le symbole PLA2G2A. Communément appelé aussi: Phospholipase A2, membrane associated; GIIC sPLA2; Group IIA Non-pancreatic secretory NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; PLA2G2A; PLA2B; PLA2L; RASF-A. Phospholipase A2 a une masse de 16.08kDa et une longueur d'acide aminé de 144.
Nous proposons 14 des anticorps contre Phospholipase A2, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et Dot avec des échantillons dérivés de Humain, Souris, Rat, Bovin et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).
Résumé Entrez
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene.
Similitudes de séquence
Belongs to the phospholipase A2 family.
Localisation cellulaire
Cell membrane. Secreted.
