Perilipin 3 est un gène codé par le symbole PLIN3. Communément appelé aussi: Perilipin-3; 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; Placental protein 17; PP17; PLIN3; M6PRBP1; TIP47. Perilipin 3 a une masse de 47.08kDa et une longueur d'acide aminé de 434.
Nous proposons 5 des anticorps contre Perilipin 3, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
Résumé Entrez
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
Similitudes de séquence
Belongs to the perilipin family.
Localisation cellulaire
Cytoplasm. Endosome membrane. Lipid droplet.
Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails.
