PDE8A est un gène codé par le symbole PDE8A. Il est également connu sous le nom de High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A. PDE8A a une masse de 93.3kDa et une longueur d'acide aminé de 829.
Nous proposons 12 des anticorps contre PDE8A, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).
Résumé Entrez
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
Similitudes de séquence
Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
Modification post-traductionnelle
Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.
