PDE1A est un gène codé par le symbole PDE1A. Communément appelé aussi: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; 61 kDa Cam-PDE; hCam-1. PDE1A a une masse de 61.25kDa et une longueur d'acide aminé de 535.
Nous proposons 9 des anticorps contre PDE1A, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Résumé Entrez
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001
Spécificité tissulaire
Several tissues, including brain, kidney, testes and heart.
Similitudes de séquence
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
