PDE10A est un gène codé par le symbole PDE10A. Il est également connu sous le nom de cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A. PDE10A a une masse de 88.41kDa, une longueur d'acide aminé de 779, et est impliqué dans les maladies: Dyskinesia, limb and orofacial, infantile-onset; Striatal degeneration, autosomal dominant 2.
Nous proposons 10 des anticorps contre PDE10A, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Résumé Entrez
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Spécificité tissulaire
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Implication dans la maladie
Dyskinesia, limb and orofacial, infantile-onset: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.
Striatal degeneration, autosomal dominant 2: An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
Similitudes de séquence
Belongs to the cyclic nucleotide phosphodiesterase family.
Modification post-traductionnelle
Phosphorylated on Thr-16.
Localisation cellulaire
Cytoplasm.
Located mostly to soluble cellular fractions.
