Pannexin 1 est un gène codé par le symbole PANX1. Communément appelé aussi: Pannexin-1; PANX1; MRS1. Pannexin 1 a une masse de 48.05kDa, une longueur d'acide aminé de 426, et est impliqué dans Oocyte maturation defect 7.
Nous proposons 9 des anticorps contre Pannexin 1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116).
Résumé Entrez
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.
Spécificité tissulaire
Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116).
Implication dans la maladie
Oocyte maturation defect 7: An autosomal dominant infertility disorder due to oocyte degeneration and death, which may occur before or after fertilization.
Similitudes de séquence
Belongs to the pannexin family.
Modification post-traductionnelle
S-nitrosylation inhibits channel currents and ATP release.
Localisation cellulaire
Cell membrane. Cell junction > Gap junction. Endoplasmic reticulum membrane.
