pan Synuclein est un gène codé par le symbole SNCG. Communément appelé aussi: Gamma-synuclein; Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR; SNCG; BCSG1; PERSYN; PRSN. pan Synuclein a une masse de 13.33kDa et une longueur d'acide aminé de 127.
Nous proposons 17 des anticorps contre pan Synuclein, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Bovin et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Résumé Entrez
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Similitudes de séquence
Belongs to the synuclein family.
Modification post-traductionnelle
Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
Localisation cellulaire
Cytoplasm > Perinuclear region. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle.
Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
