Anticorps PAK5

7 produits

PAK5 est un gène codé par le symbole PAK5. Communément appelé aussi: Serine/threonine-protein kinase PAK 5; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7; KIAA1264; PAK7. PAK5 a une masse de 80.75kDa et une longueur d'acide aminé de 719.

Nous proposons 7 des anticorps contre PAK5, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Résumé Entrez
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
Spécificité tissulaire
Predominantly expressed in brain.
Similitudes de séquence
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Modification post-traductionnelle
Autophosphorylated when activated by CDC42/p21.
Localisation cellulaire
Mitochondrion. Cytoplasm. Nucleus.

Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Liens de base de données
Western Blot - Anti-PAK7 Antibody (C21170) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-PAK5 Antibody (A91289) - Antibodies.com
Western blot - PAK7 Antibody from Signalway Antibody (35292) - Antibodies.com
(2)
Anti-PAK5 (E693) Antibody from Bioworld Technology (BS9193) - Antibodies.com
Western blot - PAK5 Antibody from Signalway Antibody (24182) - Antibodies.com
(2)
PAK7 Antibody from Signalway Antibody (35866) - Antibodies.com
(2)
Western blot - PAK5/6 (Phospho-Ser602/Ser560) Antibody from Signalway Antibody (11812) - Antibodies.com

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