P70 S6 Kinase beta est un gène codé par le symbole RPS6KB2. Communément appelé aussi: Ribosomal protein S6 kinase beta-2; S6K-beta-2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; RPS6KB2; STK14B. P70 S6 Kinase beta a une masse de 53.46kDa et une longueur d'acide aminé de 482.
Nous proposons 7 des anticorps contre P70 S6 Kinase beta, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
Résumé Entrez
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Similitudes de séquence
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Modification post-traductionnelle
Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
Localisation cellulaire
Cytoplasm. Nucleus.
