P2Y12 est un gène codé par le symbole P2RY12. Communément appelé aussi: P2Y purinoceptor 12; ADP-glucose receptor; ADPG-R; P2T(AC); P2Y(AC); P2Y(cyc) platelet ADP receptor; P2Y(ADP); SP1999; P2RY12; HORK3. P2Y12 a une masse de 39.44kDa, une longueur d'acide aminé de 342, et est impliqué dans Bleeding disorder, platelet-type 8.
Nous proposons 6 des anticorps contre P2Y12, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Résumé Entrez
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.
Spécificité tissulaire
Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
Implication dans la maladie
Bleeding disorder, platelet-type 8: A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family.
Localisation cellulaire
Cell membrane.
