Ornithine Decarboxylase est un gène codé par le symbole ODC1. Communément appelé aussi: ODC; ODC1. Ornithine Decarboxylase a une masse de 51.15kDa et une longueur d'acide aminé de 461.
Nous proposons 17 des anticorps contre Ornithine Decarboxylase, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Résumé Entrez
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Similitudes de séquence
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Modification post-traductionnelle
S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
