Oligodendrocyte Specific Protein est un gène codé par le symbole CLDN11. Communément appelé aussi: Claudin-11; Oligodendrocyte-specific protein; CLDN11; OSP; OTM. Oligodendrocyte Specific Protein a une masse de 21.99kDa et une longueur d'acide aminé de 207.
Nous proposons 6 des anticorps contre Oligodendrocyte Specific Protein, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Résumé Entrez
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Similitudes de séquence
Belongs to the claudin family.
Localisation cellulaire
Cell junction > Tight junction. Cell membrane.
