Nurr1 est un gène codé par le symbole NR4A2. Communément appelé aussi: Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor Transcriptionally-inducible nuclear receptor; NR4A2; NOT; TINUR. Nurr1 a une masse de 66.59kDa et une longueur d'acide aminé de 598.
Nous proposons 6 des anticorps contre Nurr1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et IP avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Résumé Entrez
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Spécificité tissulaire
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
Similitudes de séquence
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Localisation cellulaire
Cytoplasm. Nucleus.
Mostly nuclear; oxidative stress promotes cytoplasmic localization.
