Nucleostemin est un gène codé par le symbole GNL3. Communément appelé aussi: Guanine nucleotide-binding protein-like 3; E2-induced gene 3 protein; Novel nucleolar protein 47; NNP47; Nucleolar GTP-binding protein 3; GNL3; E2IG3; NS. Nucleostemin a une masse de 61.99kDa et une longueur d'acide aminé de 549.
Nous proposons 7 des anticorps contre Nucleostemin, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Résumé Entrez
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
Spécificité tissulaire
Increased levels in lung tissue in cancer patients.
Similitudes de séquence
Belongs to the TRAFAC class YlqF/YawG GTPase family.
Localisation cellulaire
Nucleus. Nucleus > Nucleolus.
Shuttles between the nucleus and nucleolus.
