NRF1 est un gène codé par le symbole NRF1. Communément appelé aussi: Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal. NRF1 a une masse de 53.54kDa et une longueur d'acide aminé de 503.
Nous proposons 11 des anticorps contre NRF1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, IP et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Résumé Entrez
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.
Spécificité tissulaire
Ubiquitously expressed with strongest expression in skeletal muscle.
Similitudes de séquence
Belongs to the NRF1/Ewg family.
Modification post-traductionnelle
Phosphorylation enhances DNA binding.
Localisation cellulaire
Nucleus.
