Nkx3.1 est un gène codé par le symbole NKX3-1. Communément appelé aussi: Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A; NKX3-1; NKX3A. Nkx3.1 a une masse de 26.35kDa et une longueur d'acide aminé de 234.
Nous proposons 25 des anticorps contre Nkx3.1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Résumé Entrez
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
Spécificité tissulaire
Highly expressed in the prostate and, at a lower level, in the testis.
Similitudes de séquence
Belongs to the NK-3 homeobox family.
Modification post-traductionnelle
Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
Localisation cellulaire
Nucleus.
