Anticorps NIRF

8 produits

NIRF est un gène codé par le symbole UHRF2. Communément appelé aussi: E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2; UHRF2; RNF107. NIRF a une masse de 89.99kDa et une longueur d'acide aminé de 802.

Nous proposons 8 des anticorps contre NIRF, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
Résumé Entrez
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
Modification post-traductionnelle
May be autoubiquitinated; which may lead to proteasomal degradation.
Localisation cellulaire
Nucleus.

Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity).
Immunohistochemistry - Anti-NIRF Antibody (A92417) - Antibodies.com
(4)
Western Blot - Anti-Uhrf2 Antibody (A13976) - Antibodies.com
Western Blot - Anti-Uhrf2 Antibody (A92497) - Antibodies.com
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Anti-UHRF2 Antibody from Bioworld Technology (BS7228) - Antibodies.com
Western blot - UHRF2 antibody from Signalway Antibody (38400) - Antibodies.com
Immunohistochemistry - UHRF2 Antibody from Signalway Antibody (37761) - Antibodies.com
(2)

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