NFAT5 est un gène codé par le symbole NFAT5. Communément appelé aussi: Nuclear factor of activated T-cells 5; NF-AT5; T-cell transcription factor Tonicity-responsive enhancer-binding protein; TonE-binding protein; KIAA0827; TONEBP. NFAT5 a une masse de 165.76kDa et une longueur d'acide aminé de 1531.
Nous proposons 7 des anticorps contre NFAT5, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394).
Résumé Entrez
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.
Modification post-traductionnelle
Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322).
Localisation cellulaire
Nucleus. Cytoplasm.
Nuclear distribution increases under hypertonic conditions.
