Neurotrophin 4 est un gène codé par le symbole NTF4. Communément appelé aussi: Neurotrophin-4; NT-4; Neurotrophin-5; NT-5; Neutrophic factor 4; NTF4; NTF5. Neurotrophin 4 a une masse de 22.43kDa, une longueur d'acide aminé de 210, et est impliqué dans Glaucoma 1, open angle, O.
Nous proposons 6 des anticorps contre Neurotrophin 4, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Target-derived survival factor for peripheral sensory sympathetic neurons.
Résumé Entrez
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
Spécificité tissulaire
Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
Implication dans la maladie
Glaucoma 1, open angle, O: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Similitudes de séquence
Belongs to the NGF-beta family.
Localisation cellulaire
Secreted.
