Neuropeptide Y est un gène codé par le symbole NPY. Il est également connu sous le nom de Pro-NPY. Neuropeptide Y a une masse de 10.85kDa et une longueur d'acide aminé de 97.
Nous proposons 6 des anticorps contre Neuropeptide Y, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Résumé Entrez
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
Spécificité tissulaire
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Similitudes de séquence
Belongs to the NPY family.
Modification post-traductionnelle
The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Localisation cellulaire
Secreted. Cytoplasmic vesicle > Secretory vesicle > Neuronal dense core vesicle.
