NEK7 est un gène codé par le symbole NEK7. Communément appelé aussi: Serine/threonine-protein kinase Never in mitosis A-related kinase 7; NimA-related protein kinase 7. NEK7 a une masse de 34.55kDa et une longueur d'acide aminé de 302.
Nous proposons 7 des anticorps contre NEK7, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.
Résumé Entrez
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.
Spécificité tissulaire
Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
Similitudes de séquence
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Modification post-traductionnelle
Phosphorylation at Ser-195 required for its activation.
Localisation cellulaire
Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Spindle pole. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.
Present at centrosome throughout the cell cycle (PubMed:17586473). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (PubMed:17586473). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity).
