NCR3 est un gène codé par le symbole NCR3. Communément appelé aussi: Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; 1C7; LY117. NCR3 a une masse de 21.59kDa et une longueur d'acide aminé de 201.
Nous proposons 10 des anticorps contre NCR3, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Résumé Entrez
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
Similitudes de séquence
Belongs to the natural cytotoxicity receptor (NCR) family.
Localisation cellulaire
Cell membrane.
