NCOA4 est un gène codé par le symbole NCOA4. Communément appelé aussi: Nuclear receptor coactivator 4; NCoA-4; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1; ARA70; ELE1; RFG. NCOA4 a une masse de 69.73kDa et une longueur d'acide aminé de 614.
Nous proposons 2 des anticorps contre NCOA4, élevé dans Lapin, qui sont appropriés pour le WB et IHC avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.
Résumé Entrez
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
Spécificité tissulaire
Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.
