NAPSIN A est un gène codé par le symbole NAPSA. Communément appelé aussi: Napsin-A; Aspartyl protease 4; ASP4; Napsin-1; TA01/TA02; NAPSA; NAP1; NAPA. NAPSIN A a une masse de 45.39kDa et une longueur d'acide aminé de 420.
Nous proposons 46 des anticorps contre NAPSIN A, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux, IP et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May be involved in processing of pneumocyte surfactant precursors.
Résumé Entrez
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma.
Spécificité tissulaire
Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.
Similitudes de séquence
Belongs to the peptidase A1 family.
Localisation cellulaire
Secreted.
