Myeloid leukemia factor 1 est un gène codé par le symbole MLF1. Il est également connu sous le nom de Myelodysplasia-MLF1. Myeloid leukemia factor 1 a une masse de 30.63kDa et une longueur d'acide aminé de 268.
Nous proposons 6 des anticorps contre Myeloid leukemia factor 1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Résumé Entrez
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Similitudes de séquence
Belongs to the MLF family.
Modification post-traductionnelle
Phosphorylation is required for binding to YWHAZ.
Localisation cellulaire
Cytoplasm. Nucleus. Cell projection > Cilium. Cytoplasm > Cytoskeleton > Cilium basal body.
Shuttles between the cytoplasm and nucleus.
