Myelin oligodendrocyte glycoprotein est un gène codé par le symbole MOG. Communément appelé aussi: Myelin-oligodendrocyte glycoprotein; MOG. Myelin oligodendrocyte glycoprotein a une masse de 28.19kDa, une longueur d'acide aminé de 247, et est impliqué dans Narcolepsy 7.
Nous proposons 5 des anticorps contre Myelin oligodendrocyte glycoprotein, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
Résumé Entrez
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Spécificité tissulaire
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Implication dans la maladie
Narcolepsy 7: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Localisation cellulaire
Cell membrane.
