MUC2 est un gène codé par le symbole MUC2. Communément appelé aussi: Mucin-2; MUC-2; Intestinal mucin-2; SMUC. MUC2 a une masse de 540.3kDa et une longueur d'acide aminé de 5179.
Nous proposons 19 des anticorps contre MUC2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Résumé Entrez
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
Spécificité tissulaire
Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Modification post-traductionnelle
O-glycosylated.
Localisation cellulaire
Secreted.
In the intestine, secreted into the inner and outer mucus layers.
