MST4 est un gène codé par le symbole STK26. Communément appelé aussi: Serine/threonine-protein kinase 26; MST3 and SOK1-related kinase; Mammalian STE20-like protein kinase 4; MST-4; Serine/threonine-protein kinase MASK; STK26; MASK. MST4 a une masse de 46.53kDa et une longueur d'acide aminé de 416.
Nous proposons 7 des anticorps contre MST4, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).
Résumé Entrez
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Similitudes de séquence
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Localisation cellulaire
Cytoplasm. Golgi apparatus.
Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006).
