Anticorps MSH2

26 produits

MSH2 est un gène codé par le symbole MSH2. Il est également connu sous le nom de DNA mismatch repair protein hMutS protein homolog 2. MSH2 a une masse de 104.74kDa, une longueur d'acide aminé de 934, et est impliqué dans les maladies: Hereditary non-polyposis colorectal cancer 1; Muir-Torre syndrome; Endometrial cancer; Mismatch repair cancer syndrome; Colorectal cancer.

Nous proposons 26 des anticorps contre MSH2, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.

Informations sur les Gènes et les Protéines

Résumé UniProt
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
Résumé Entrez
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Ubiquitously expressed.
Implication dans la maladie
Hereditary non-polyposis colorectal cancer 1: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.

Muir-Torre syndrome: Rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy.

Endometrial cancer: A malignancy of endometrium, the mucous lining of the uterus. Most endometrial cancers are adenocarcinomas, cancers that begin in cells that make and release mucus and other fluids.

Mismatch repair cancer syndrome: An autosomal recessive, rare, childhood cancer predisposition syndrome encompassing a broad tumor spectrum. This includes hematological malignancies, central nervous system tumors, Lynch syndrome-associated malignancies such as colorectal tumors as well as multiple intestinal polyps, embryonic tumors and rhabdomyosarcoma. Multiple cafe-au-lait macules, a feature reminiscent of neurofibromatosis type 1, are often found as first manifestation of the underlying cancer. Areas of skin hypopigmentation have also been reported in MMRCS patients.

Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Similitudes de séquence
Belongs to the DNA mismatch repair MutS family.
Modification post-traductionnelle
Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.
Localisation cellulaire
Nucleus. Chromosome.
Immunohistochemistry - Anti-MSH2 Antibody [MSH2/2622] - BSA and Azide free (A252561) - Antibodies.com
(8)
Immunohistochemistry - Anti-MSH2 Antibody [MSH2/2622] (A249381) - Antibodies.com
(8)
Immunofluorescence - Anti-MSH2 Antibody (C13089) - Antibodies.com
(2)
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-MSH2 Antibody [ARC1285] (A307085) - Antibodies.com
(3)
Western Blot - Anti-MSH2 Antibody (A307086) - Antibodies.com
(3)
Voir le roduitKO Validé
Immunohistochemistry - Anti-MSH2 Antibody [rMSH2/6548] - BSA and Azide free (A252560) - Antibodies.com
(4)
Voir le roduitAnticorps Recombinant
Immunohistochemistry - Anti-MSH2 Antibody [rMSH2/6548] (A249380) - Antibodies.com
(4)
Voir le roduitAnticorps Recombinant
Immunohistochemistry - Anti-MSH2 Antibody [MSH2/6549R] - BSA and Azide free (A252562) - Antibodies.com
(4)
Voir le roduitAnticorps Recombinant
Western Blot - Anti-MSH2 Antibody (A1121) - Antibodies.com
(2)
Immunohistochemistry - Anti-MSH2 Antibody [MSH2/6549R] (A249382) - Antibodies.com
(4)
Voir le roduitAnticorps Recombinant
Immunohistochemistry - Anti-MSH2 Antibody [MSH2/6852] - BSA and Azide free (A278305) - Antibodies.com
(3)
Immunohistochemistry - Anti-MSH2 Antibody [MSH2/6852] (A277717) - Antibodies.com
(3)
Immunohistochemistry - Anti-MSH2 Antibody [RM375] (A121390) - Antibodies.com
(2)
Voir le roduitAnticorps Recombinant
Western Blot - Anti-MSH2 Antibody (A306654) - Antibodies.com
(2)
Voir le roduitKO Validé
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Immunohistochemistry - Anti-MSH2 Antibody [IHC510] (A324479) - Antibodies.com
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Voir le roduitAnticorps Recombinant
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Western blot - MSH2 Antibody from Signalway Antibody (32169) - Antibodies.com
(4)
Anti-MSH2 Antibody from Bioworld Technology (BS6056) - Antibodies.com
(3)
Immunohistochemistry - MSH2 Antibody from Signalway Antibody (34289) - Antibodies.com
(2)
Anti-MSH2 Antibody from Bioworld Technology (MB0152) - Antibodies.com
(2)
MSH2 Antibody from Signalway Antibody (35358) - Antibodies.com
Anti-MSH2 Antibody from Bioworld Technology (BS61570) - Antibodies.com

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