MMP8 est un gène codé par le symbole MMP8. Communément appelé aussi: Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; CLG1. MMP8 a une masse de 53.41kDa et une longueur d'acide aminé de 467.
Nous proposons 8 des anticorps contre MMP8, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Can degrade fibrillar type I, II, and III collagens.
Résumé Entrez
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Neutrophils.
Similitudes de séquence
Belongs to the peptidase M10A family.
Localisation cellulaire
Cytoplasmic granule. Secreted > Extracellular space > Extracellular matrix.
Stored in intracellular granules.
