MMP19 est un gène codé par le symbole MMP19. Communément appelé aussi: Matrix metalloproteinase-19; MMP-19; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18; MMP18; RASI. MMP19 a une masse de 57.36kDa, une longueur d'acide aminé de 508, et est impliqué dans Cavitary optic disc anomalies.
Nous proposons 6 des anticorps contre MMP19, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Résumé Entrez
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene.
Spécificité tissulaire
Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941).
Implication dans la maladie
Cavitary optic disc anomalies: An ocular disease characterized by a profound excavation of the optic nerve. Clinical phenotype is variable and includes congenitally excavated optic nerves as well as other features of optic pit, optic nerve coloboma, and morning glory disk anomaly. Patients with CODA have a strong predilection for retinal detachment and/or separation of the retinal layers (retinoschisis) that lead to profound central vision loss.
Similitudes de séquence
Belongs to the peptidase M10A family.
Modification post-traductionnelle
Activated by autolytic cleavage after Lys-97.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
