MMP16 est un gène codé par le symbole MMP16. Communément appelé aussi: Matrix metalloproteinase-16; MMP-16; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; C8orf57; MMPX2. MMP16 a une masse de 69.52kDa et une longueur d'acide aminé de 607.
Nous proposons 6 des anticorps contre MMP16, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Résumé Entrez
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Spécificité tissulaire
Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
Similitudes de séquence
Belongs to the peptidase M10A family.
Modification post-traductionnelle
The precursor is cleaved by a furin endopeptidase.
Localisation cellulaire
Cell membrane.
Localized at the cell surface of melanoma cells.
