MMP11 est un gène codé par le symbole MMP11. Communément appelé aussi: Stromelysin-3; SL-3; Matrix metalloproteinase-11; MMP-11; STMY3. MMP11 a une masse de 54.59kDa et une longueur d'acide aminé de 488.
Nous proposons 11 des anticorps contre MMP11, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May play an important role in the progression of epithelial malignancies.
Résumé Entrez
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Spécificité tissulaire
Specifically expressed in stromal cells of breast carcinomas.
Similitudes de séquence
Belongs to the peptidase M10A family.
Modification post-traductionnelle
The precursor is cleaved by a furin endopeptidase.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
