Microsomal Glutathione S-transferase 1 est un gène codé par le symbole MGST1. Communément appelé aussi: Microsomal GST-1; Microsomal GST-I; MGST1; GST12; MGST. Microsomal Glutathione S-transferase 1 a une masse de 17.6kDa et une longueur d'acide aminé de 155.
Nous proposons 7 des anticorps contre Microsomal Glutathione S-transferase 1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
Résumé Entrez
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene.
Spécificité tissulaire
Highly expressed in liver.
Similitudes de séquence
Belongs to the MAPEG family.
Modification post-traductionnelle
Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
Localisation cellulaire
Microsome. Mitochondrion outer membrane. Endoplasmic reticulum membrane.
