Metallothionein est un gène codé par le symbole MT2A. Communément appelé aussi: Metallothionein-2; MT-2-2A-II; MT-II; MT2A; CES1; MT2. Metallothionein a une masse de 6.04kDa et une longueur d'acide aminé de 61.
Nous proposons 9 des anticorps contre Metallothionein, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Résumé Entrez
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity.
Similitudes de séquence
Belongs to the metallothionein superfamily. Type 1 family.
