Mesothelin est un gène codé par le symbole MSLN. Communément appelé aussi: CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor; MSLN; MPF. Mesothelin a une masse de 68.99kDa et une longueur d'acide aminé de 630.
Nous proposons 36 des anticorps contre Mesothelin, élevé dans Lapin, Souris, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Membrane-anchored forms may play a role in cellular adhesion.
Résumé Entrez
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Spécificité tissulaire
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Similitudes de séquence
Belongs to the mesothelin family.
Modification post-traductionnelle
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Localisation cellulaire
Cell membrane. Golgi apparatus.
