MelanA est un gène codé par le symbole MLANA. Communément appelé aussi: Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MLANA; MART1. MelanA a une masse de 13.16kDa et une longueur d'acide aminé de 118.
Nous proposons 44 des anticorps contre MelanA, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ICC/IF, Cytométrie en Flux et ChIP avec des échantillons dérivés de Humain, Souris, Rat, Canin et Cheval.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Spécificité tissulaire
Expression is restricted to melanoma and melanocyte cell lines and retina.
Modification post-traductionnelle
Acylated.
Localisation cellulaire
Endoplasmic reticulum membrane. Golgi apparatus. Golgi apparatus > trans-Golgi network membrane. Melanosome.
Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
