MEK5 est un gène codé par le symbole MAP2K5. Communément appelé aussi: Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MEK 5; MAP2K5; MKK5; PRKMK5. MEK5 a une masse de 50.11kDa et une longueur d'acide aminé de 448.
Nous proposons 7 des anticorps contre MEK5, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Poulet, Canin, Xenopus et Poisson Zèbre.
Informations sur les Gènes et les Protéines
Résumé UniProt
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Résumé Entrez
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Spécificité tissulaire
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Similitudes de séquence
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Modification post-traductionnelle
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
