MCM6 est un gène codé par le symbole MCM6. Il est également connu sous le nom de DNA replication licensing factor p105MCM. MCM6 a une masse de 92.89kDa et une longueur d'acide aminé de 821.
Nous proposons 11 des anticorps contre MCM6, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et ChIP avec des échantillons dérivés de Humain, Souris, Rat et S. pombe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Résumé Entrez
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Similitudes de séquence
Belongs to the MCM family.
Modification post-traductionnelle
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Localisation cellulaire
Nucleus.
Binds to chromatin during G1 and detach from it during S phase.
