MCL1 est un gène codé par le symbole MCL1. Communément appelé aussi: Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1/EAT; BCL2L3. MCL1 a une masse de 37.34kDa et une longueur d'acide aminé de 350.
Nous proposons 23 des anticorps contre MCL1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Résumé Entrez
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Similitudes de séquence
Belongs to the Bcl-2 family.
Modification post-traductionnelle
Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Localisation cellulaire
Membrane. Cytoplasm. Mitochondrion. Nucleus > Nucleoplasm.
Cytoplasmic, associated with mitochondria.
